The Toxicity over Time (ToxT) was developed by Gita Thanarajasingam, MD, to study the side effects (adverse events) of cancer treatments over time. This method allows for investigators to carefully examine the data collected from patients at different points in time throughout a clinical trial. In essence, the ToxT method helps researchers dig deeper into the data from cancer clinical trials to better understand how the side effects of treatments changed over the course of the trials. This information can be valuable for improving cancer treatments and the overall care of cancer patients.

The ToxT SAS macros can be found here: http://bioinformaticstools.mayo.edu/research/toxt/

For more information on ToxT, we recommend reading the following papers:

Longitudinal adverse event assessment in oncology clinical trials: the Toxicity over Time (ToxT) analysis of Alliance trials NCCTG N9741 and 979254 - Thanarajasingam et al, 2016

Adverse event development in clinical oncology trials - Authors’ reply - Thanarajasingam et al, 2016

Longitudinal Toxicity over Time (ToxT) analysis to evaluate tolerability: a case study of lenalidomide in the CALGB 50401 (Alliance) trial - Thanarajasingam et al, 2020

Expanding Beyond Maximum Grade: Chemotherapy Toxicity over Time by Age and Performance Status in Advanced Non-Small Cell Lung Cancer in CALGB 9730 (Alliance A151729) - Wong et al, 2021

If you’re interested in using ToxT or want to discuss more, feel free to contact our team! DueckLab@mayo.edu